Osteoporosis and periodontitis: a bidirectional relationship

Authors

  • Paramjit Kaur Khinda Department of Periodontology – Genesis Institute of Dental sciences and Research – Punjab – India.

DOI:

https://doi.org/10.14295/bds.2017.v20i2.1247

Abstract

Osteoporosis is a condition of compromised bone strength that predisposes an individual to increased risk of fracture and is a major cause of morbidity in older susceptible individuals. Osteoporosis is related to various endocrinal abnormalities, metabolic and nutritional factors, postmenopausal hormonal changes and consumption of certain drugs such as cortisone. Emerging clinical and molecular evidence suggests that inflammation also exerts significant influence on osteoporotic bone changes. Numerous pro-inflammatory cytokines have been shown to be associated with regulation of osteoblast and osteoclast differentiation. Chronic inflammatory conditions causing immune system remodeling may serve as pathological risk factors for osteoporosis. The present article reviews the current perspective on the interaction between bone morphology and immune system in the inflammatory condition (periodontitis), unleashing the link between two chronic conditions.

Keywords

Osteoporosis; Periodontitis; Inflammation; Bone remodelling.

Author Biography

Paramjit Kaur Khinda, Department of Periodontology – Genesis Institute of Dental sciences and Research – Punjab – India.

 

 

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Published

2017-06-28

Issue

Vol. 20 No. 2 (2017): Apr. - Jun. / 2017 - Published Jun 2017

Section

Literature Review

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We hereby attest the study is original and does not present manipulated data, fraud or plagiarism. We made significant scientific contribution to the study and we are aware of the presented data and in agreement with the final version of the manuscript. We assume complete responsibility for the ethical aspects of the study.

 

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