Langerhans cell histiocytosis (histiocytosis x) – in the mandible

Angela Jordão Camargo, Mayara Cheade, Celso Martinelli, Solange Aparecida Caldeira Monteiro, Christiano de Oliveira Santos, Plauto Christopher Aranha Watanabe


This article reports a case of 65 year-old man consultedin a private radiology dental clinic for a panoramicradiography, where was indicated a radiolucent area,extending into the periapical region of the teeth 35 to 43 to the base of the mandible. Radiographydiagnosis was difficult. The immunohistochemical examination showed immunoreactivity for theproteins CD 68, S-100 and CD 1a. Histopathologicaldiagnosis was obtained for Langerhans cell granuloma(histiocytosis X). Langerhans cell histiocytosis iscaused by the abnormal proliferation of histiocytes, previously called Histiocytosis X. It is a rare diseasethat preferentially affects children and young adultswith a predilection for males and can affect differentparts of the body.

Adult; Histiocytosis; Langerhans; Mandible.

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