Preventive and therapeutic effects of relaxin on bisphosphonaterelated osteonecrosis of the jaw: an experimental study in rats

Authors

DOI:

https://doi.org/10.14295/bds.2020.v23i1.1846

Abstract

Objective: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a challenging complication of chronic bisphosphonate (BP) use. The hormone relaxin is able to induce the multistep differentiation process of human osteoclastogenesis, exhibits anti-fibrotic and anti-inflammatory actions, and promotes vasodilatation, wound healing, and angiogenesis. The present study aimed to evaluate the effects of relaxin in the prevention and management of BRONJ. Material and Methods: Thirty-six male Sprague Dawley rats were randomly divided into four groups. Rats in group 1 (n = 10) received relaxin and BP simultaneously for 12 weeks. Rats in group 2 (n = 10) received injections of BP for 12 weeks, followed by relaxin for another 12 weeks. Rats in group 3 (n = 10) received only BP injections, and those in group 4 (control, n = 6) received only saline. Necrosis and inflammation in the rats’ mandibles were evaluated as indicators of BRONJ. Results: Necrosis and inflammation were not detected in group 1 (BP + relaxin). In group 3 (BP only), incidence rates of necrosis and inflammation were 90% and 60%, respectively. Conclusions: Our findings suggest that relaxin may be potently effective in preventing BRONJ and have some benefit in the treatment of existing BRONJ.

KEYWORDS

Animal model; BRONJ; Relaxin.

Author Biographies

Tuba Develi, Istanbul Medipol University - Department of Oral and Maxillofacial Surgery - İstanbul - Turkey.

department of oral and maxillofacial surgery

Sina Uckan, Istanbul Medipol University - Department of Oral and Maxillofacial Surgery - İstanbul - Turkey.

department of oral and maxillofacial surgery

Burak Bayram, Baskent University - Department of Oral and Maxillofacial Surgery - Ankara - Turkey.

department of oral and maxillofacial surgery

Kagan Deniz, Istanbul Baskent University - Department of Oral and Maxillofacial Surgery - Istanbul - Turkey

department of oral and maxillofacial surgery

Remzi Saban Erdem, Baskent University Medical Faculty - Department of Pharmacology - Ankara - Turkey.

Department of Pharmacology

Hannan Binnaz Ozdemir, Baskent University Medical Faculty - Department of Pathologhy - Ankara - Turkey

Department of Pathologhy

Neslihan Bascil Tutuncu, Baskent University Medical Faculty - Department of Endocrinologhy - Ankara - Turkey

Department of Endocrinologhy

Didem Bacanli, Baskent University Medical Faculty - Experimental Animals Breeding and Research Center - Ankara - Turkey.

Experimental Animals Breeding and Research Center

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Published

2020-01-31

Issue

Vol. 23 No. 1 (2020): Jan. - Mar. - Published Jan. 2020

Section

Clinical or Laboratorial Research

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