Do HIV patients have mandibular osteoporotic alterations? A mandibular cortical index case-control study
DOI:
https://doi.org/10.14295/bds.2021.v24i1.2157Abstract
Objective: The objective of this study was to evaluate mandibular osteoporotic alterations in patients with HIV infection in comparison to non-HIV-infected patients using panoramic radiographs. Material and Methods: 26 HIV-infected patients and 142 non-HIV-infected patients (control group) were included in this study. Panoramic radiographs of the participants were assessed considering mandibular cortical index (MCI). Non-parametric comparisons between groups were performed, using Mann-Whitney test, at a level significance level of p= 0.05. Results: HIV-infected patients presented lower bone mineral density (BMD) at mandible, assessed by MCI in panoramic radiographs when compared to non-HIV-infected patients. The medication intake of HIV-infected patients was highly heterogeneous and could not be associated to the low BMD presented in the mandibular cortex. Conclusions: HIV-infected patients may present lower mandibular BMD than non-HIV-infected patients.
Keywords
Panoramic radiograph; osteoporosis; bone mineral density; HIV.
References
Brody C, Sok S, Tuot S, Pantelic M, Restoy E, Yi S. Do combination HIV prevention programmes result in increased empowerment, inclusion and agency to demand equal rights for marginalised populations in low-income and middle-income countries? A systematic review. BMJ Glob Health. 2019 Out;4(5):e001560. doi: 10.1136/bmjgh-2019-001560
Rodger AJ, Lodwick R, Schechter M, Deeks S, Amin J, Gilson R, et al. Mortality in well controlled HIV in the continuous antiretroviral therapy arms of the SMART and ESPRIT trials compared with the general population. AIDS. 2013 Mar;27(6):973-9.doi: 10.1097/QAD.0b013e32835cae9c
Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013 Oct;8:136. doi: 10.1007/s11657-013-0136-1.
Marinho BC, Guerra LP, Drummond JB, Silva BC, Soares MM. The burden of osteoporosis in Brazil. Arq Bras Endocrinol Metabol. 2014 Jul;58(5):434-43. doi:10.1590/0004-2730000003203
Baccaro LF, Conde DM, Costa-Paiva L, Pinto-Neto AM. The epidemiology and management of postmenopausal osteoporosis: a viewpoint from Brazil. Clin Interv Aging. 2015 Mar;10:583-91.doi: 10.2147/CIA.S54614
Munhoz L CI, Miura DK, Watanabe PCA, Arita ES. Bone mineral density and mandibular osteoporotic alterations in panoramic radiographs: Correlation by peripheral bone densitometry in men. Indian J Den Res. 2019.
Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994 Jun;843:1-129.
Nayak S, Edwards DL, Saleh AA, Greenspan SL. Systematic review and meta-analysis of the performance of clinical risk assessment instruments for screening for osteoporosis or low bone density. Osteoporos Int. 2015 Feb;26(5):1543-54.doi: 10.1007/s00198-015-3025-1
Garg MK, Kharb S. Dual energy X-ray absorptiometry: Pitfalls in measurement and interpretation of bone mineral density. Indian J Endocrinol Metab. 2013 Mar;17(2):203-10.doi: 10.4103/2230-8210.109659
Blake GM, Fogelman I. The role of DXA bone density scans in the diagnosis and treatment of osteoporosis. Postgrad Med J. 2007 Mar;83(982):509-17.doi: 10.1136/pgmj.2007.057505
Kim OS, Shin MH, Song IH, Lim IG, Yoon SJ, Kim OJ, et al. Digital panoramic radiographs are useful for diagnosis of osteoporosis in Korean postmenopausal women. Gerodontology. 2016 Jun;33(2):185-92.doi: 10.1111/ger.12134
Wan CS, Ward LC, Halim J, Gow ML, Ho M, Briody JN, et al. Bioelectrical impedance analysis to estimate body composition, and change in adiposity, in overweight and obese adolescents: comparison with dual-energy x-ray absorptiometry. BMC Pediatr. 2014 Oct;14:249. doi: 10.1186/1471-2431-14-249
Choi I, Munhoz L, Arita ES. Assessment of Osteoporotic Alterations in Brazilian Postmenopausal Women: A Retrospective Study. Journal of Clinical and Dental Research. 2018 May;12(5):ZC34-ZC7. doi: 10.7860/JCDR/2018/34529.11566
Munhoz L, Aoki EM, Cortes ARG, de Freitas CF, Arita ES. Osteoporotic alterations in a group of different ethnicity Brazilian postmenopausal women: An observational study. Gerodontology. 2018; 35(2):101-109. doi: 10.1111/ger.12322.
Klemetti E, Kolmakov S, Kröger H. Pantomography in assessment of the osteoporosis risk group. Scand J Dent Res. 1994 Jun;102(1):68-72. doi: 10.1111/j.1600-0722.1994.tb01156.x
Mallon PWG. Aging with HIV: osteoporosis and fractures. Current opinion in HIV and AIDS. 2014 Jul;9(4):428-35. doi: 10.1097/COH.0000000000000080
Mallon PWG. HIV and bone mineral density. Current Opinion in Infectious Diseases. 2010 Feb;23(1):1-8.doi: 10.1097/QCO.0b013e328334fe9a.
Mallon PW. HIV and bone mineral density. Curr Opin Infect Dis. 2010 Feb;23(1):1-8.doi: 10.1097/QCO.0b013e328334fe9a.
Brown TT, Qaqish RB. Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review. Aids Mar. 2006;20(17):2165-74.doi: 10.1097/QAD.0b013e32801022eb
Slama L, Reddy S, Phair J, Palella FJ, Jr., Brown TT. Changes in bone turnover markers with HIV seroconversion and ART initiation. J Antimicrob Chemother. 2017 Oct;72(5):1456-61.doi: 0.1093/jac/dkx011
Billington EO, Reid IR. Pathogenesis of Osteoporosis. In: Huhtaniemi I, Martini L, editors. Encyclopedia of Endocrine Diseases (Second Edition). Oxford: Academic Press; 2019. p. 222-32.
Armas LAG, Recker RR. Pathophysiology of Osteoporosis: New Mechanistic Insights. Endocrinology and Metabolism Clinics of North America. 2012 Sep;41(3):475-86.doi: 10.1016/j.ecl.2012.04.006
Triant VA, Brown TT, Lee H, Grinspoon SK. Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system. J Clin Endocrinol Metab. 2008 Sep;93(9):3499-504.doi: 10.1210/jc.2008-0828
Lemos CAA, Verri FR, Cruz RS, Santiago Junior JF, Faverani LP, Pellizzer EP. Survival of dental implants placed in HIV-positive patients: a systematic review. Int J Oral Maxillofac Surg. 2018 Oct;47(10):1336-42.doi: 10.1016/j.ijom.2018.02.010
Rubinstein NC, Jacobson Z, McCausland GL, Dibart S. Retrospective study of the success of dental implants placed in HIV-positive patients. Int J Implant Dent. 2019 Jun;5(1):30. doi: 10.1186/s40729-019-0174-6
de Medeiros F, Kudo GAH, Leme BG, Saraiva PP, Verri FR, Honorio HM, et al. Dental implants in patients with osteoporosis: a systematic review with meta-analysis. Int J Oral Maxillofac Surg. 2018 Apr;47(4):480-91.doi: 10.1016/j.ijom.2017.05.021
Caputo BV, Traversa-Caputo GC, Costa C, Giovani EM. Evaluation of bone alterations in the jaws of HIV-infected menopausal women. Brazilian Oral Research. 2013 Apr;27:231-7.doi: 10.1590/S1806-83242013005000014
Klemetti E, Kolmakov S, Kroger H. Pantomography in assessment of the osteoporosis risk group. Scand J Dent Res. 1994 Fev;102(1):68-72. doi: 0.1111/j.1600-0722.1994.tb01156.x
Calciolari E, Donos N, Park JC, Petrie A, Mardas N. Panoramic measures for oral bone mass in detecting osteoporosis: a systematic review and meta-analysis. J Dent Res. 2015 Nov;94(3 Suppl):17s-27s. doi: 10.1177/0022034514554949
Taguchi A, Asano A, Ohtsuka M, Nakamoto T, Suei Y, Tsuda M, et al. Observer performance in diagnosing osteoporosis by dental panoramic radiographs: results from the osteoporosis screening project in dentistry (OSPD). Bone. 2008 Jul;43(1):209-13.doi: 10.1016/j.bone.2008.03.014
Taguchi A. Triage screening for osteoporosis in dental clinics using panoramic radiographs. Oral Dis. 2010 Jul;16(4):316-27. doi: 10.1016/j.bone.2008.03.014
Bandera A, Gori A, Clerici M, Sironi M. Phylogenies in ART: HIV reservoirs, HIV latency and drug resistance. Curr Opin Pharmacol. 2019;48:24-32.
Arts EJ, Hazuda DJ. HIV-1 antiretroviral drug therapy. Cold Spring Harb Perspect Med. 2012 Oct;2(4):a007161.doi: 10.1016/j.coph.2019.03.003
McComsey GA, Kitch D, Daar ES, Tierney C, Jahed NC, Tebas P, et al. Bone mineral density and fractures in antiretroviral-naive persons randomized to receive abacavir-lamivudine or tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG A5202. J Infect Dis. 2011 Jun;203(12):1791-801.doi: 10.1093/infdis/jir188
Brown TT, Moser C, Currier JS, Ribaudo HJ, Rothenberg J, Kelesidis T, et al. Changes in Bone Mineral Density After Initiation of Antiretroviral Treatment With Tenofovir Disoproxil Fumarate/Emtricitabine Plus Atazanavir/Ritonavir, Darunavir/Ritonavir, or Raltegravir. J Infect Dis. 2015 Out ;212(8):1241-9. doi: 10.1093/infdis/jiv194
Cotter AG, Vrouenraets SM, Brady JJ, Wit FW, Fux CA, Furrer H, et al. Impact of switching from zidovudine to tenofovir disoproxil fumarate on bone mineral density and markers of bone metabolism in virologically suppressed HIV-1 infected patients; a substudy of the PREPARE study. J Clin Endocrinol Metab. 2013 Apr; 98(4):1659-66. doi: 10.1210/jc.2012-3686
