Efficacy evaluation of pepsin enzyme-based gel in chemo-mechanical caries removal on primary anterior teeth: a randomized controlled clinical study

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DOI:

https://doi.org/10.4322/bds.2022.e3538

Abstract

Objective: To evaluate the efficacy of a new pepsin enzyme-based gel compared with Carisolv as a CMCR
agent. Clinical and radiographical evaluations of recurrent caries were made 3 and 6 months after treatment.
Material and Methods: A split-mouth designed randomized controlled clinical study was carried out on 40 primary
anterior teeth of children aged between 4-7 years. Pepsin enzyme-based gel and Carisolv solution were applied
to carious lesions until complete removal of caries. The efficacy of both agents was evaluated by the number of
application times to remove all caries. Recurrent caries were evaluated clinically and radiographically after 3 and 6
months of treatment. Results: Results showed no statistically significant differences in the efficacy of caries removal
by the number of application times (P = 0.919). Concerning recurrent caries, clinical and radiographical evaluation
after three and six months showed no statistically significant differences between the two groups (P = 0.574, P =
0.547, respectively). Conclusion: Pepsin enzyme-based gel can be considered similar to Carisolv gel regarding its
efficacy as a CMCR agent for small carious lesions on primary anterior teeth in children aged 4-7 years old.


KEYWORDS
Carisolv; Chemo-mechanical caries removal; Pepsin enzyme; Caries; Minimally invasive dentistry.

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Author Biographies

Anas Rajab, Syrian Private University, Organic Chemistry Department. Damascus, Syria.

Associate Professor of Organic Chemistry Department, Syrian Private University, Damascus, Syria.

(DDS, MSc, PhD)

Rashad Shaadouh, University of Damascus Dental School, Department of Orthodontics. Damascus, Syria.

MSc student at the Department of Orthodontics, University of Damascus Dental School, Damascus, Syria (DDS)

Nikolay Tuturov , RUDN University (Peoples’ Friendship University of Russia), Department of Pediatric Dentistry and Orthodontics. Moscow, Russian Federation.

Department of Pediatric Dentistry and Orthodontics RUDN University (Peoples’ Friendship University of Russia). 6 Miklukho-Maklaya Street Moscow, 117198, Russian Federation.

Ettihad Abo Arrag, University of Damascus Dental School, Department of Pediatric Dentistry. Damascus, Syria.

Professor of Pediatric Dentistry, Department of Pediatric Dentistry, University of Damascus Dental School, Damascus, Syria (DDS, MSc, PhD)

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Published

2022-12-19

How to Cite

1.
Abo Alhuda D, Rajab A, Shaadouh R, Katbeh I, Tuturov N, Abo Arrag E. Efficacy evaluation of pepsin enzyme-based gel in chemo-mechanical caries removal on primary anterior teeth: a randomized controlled clinical study. BDS [Internet]. 2022 Dec. 19 [cited 2025 Aug. 20];25(4). Available from: https://bds.ict.unesp.br/index.php/cob/article/view/3538

Issue

Vol. 25 No. 4 (2022): Oct - Dec / 2022 - Published Sep 2022

Section

Clinical or Laboratorial Research

License

Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.

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