Methotrexate delayed wound healing of a pyogenic granuloma in a child with juvenile idiopathic arthritis.

Authors

  • Lígia Ângelo Tavares Schwarzmeier Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campos.
  • Dárcio Kitakawa Prefeitura Municipal de São Paulo and Suzano, Dentistry, CK Estomatologia, SP
  • Luiz Eduardo Blumer Rosa Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campos.
  • Luiz Antonio Guimarães Cabral Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campos.
  • Janete Dias Almeida Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campos.

DOI:

https://doi.org/10.14295/bds.2019.v22i4.1714

Abstract

A nine-year-old girl with of juvenile idiopathic arthritis (JIA) in use of methotrexate complained of a self-bleeding ulcerated lesion exhibiting a red surface in the lower lip. Pyogenic granuloma was confirmed by histopathological analysis. After the 7th and 15th days, the lip where biopsy had been done exhibited a deficient healing. The case was discussed with the physician for temporary suspension of methotrexate. Complete wound healing of the biopsied site occurred after temporary interruption of the medication. Wound healing after methotrexate temporary suspension allowed concluding that the drug delayed surgical wound healing was a consequence of drug cytotoxicity.

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Author Biographies

Lígia Ângelo Tavares Schwarzmeier, Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campos.

Departamento de Biociências e Diagnóstico Bucal

Luiz Eduardo Blumer Rosa, Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campos.

Departamento de Biociências e Diagnóstico Bucal

Luiz Antonio Guimarães Cabral, Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campos.

Departamento de Biociências e Diagnóstico Bucal

Janete Dias Almeida, Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campos.

Departamento de Biociências e Diagnóstico Bucal

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Published

2019-10-31

How to Cite

1.
Schwarzmeier L Ângelo T, Kitakawa D, Rosa LEB, Cabral LAG, Almeida JD. Methotrexate delayed wound healing of a pyogenic granuloma in a child with juvenile idiopathic arthritis. BDS [Internet]. 2019 Oct. 31 [cited 2025 Oct. 12];22(4):569-72. Available from: https://bds.ict.unesp.br/index.php/cob/article/view/1714

Issue

Vol. 22 No. 4 (2019): Oct. - Dec. / 2019 - Published October 2019

Section

Case Report or Clinical Technique

License

Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.

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