Efficacy of quercetin nano-emulgel as adjuvant local delivery drug in non-surgical treatment of periodontitis

Authors

  • Khoshoe Al-mokhtar Mohammed Assiut University, Faculty of Dentistry, Department of Oral Medicine, Periodontology, and Oral Diagnosis. Assiut, Egypt. https://orcid.org/0009-0002-7269-8578
  • Alzahraa A. Alghriany Assiut University, Faculty of Dentistry, Department of Oral Medicine, Periodontology, and Oral Diagnosis. Assiut, Egypt. https://orcid.org/0009-0009-8150-8255
  • Abdullah Ibrahim Abd Rabbouh Ali Al-Azhar University, Assiut Branch, Faculty of Dental Medicine, Department of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology. Assiut, Egypt. https://orcid.org/0009-0008-8514-210X
  • Helal F Hetta University of Tabuk, Faculty of Pharmacy, Department of Natural Products and Alternative Medicine, Division of Microbiology, Immunology and Biotechnology. Tabuk, Saudi Arabia. https://orcid.org/0000-0001-8541-7304
  • Ibrahim M Mwafey Al-Azhar University, Assiut Branch, Faculty of Dental Medicine, Department of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology. Assiut, Egypt. https://orcid.org/0009-0006-8106-9537

DOI:

https://doi.org/10.4322/bds.2024.e4419

Abstract

Objective: The objective of this study was to assess the impact of quercetin nano-emulgel on clinical and biochemical markers in patients with stage I and II periodontitis as an adjuvant to scaling and root planing (SRP). Material and Methods: Two groups were randomly assigned to 20 test sites from patients with stage I and II periodontitis: Group I, in which 10 sites got scaling and root planing, and Group II, in which 10 sites received scaling and root planing alongside quercetin nano-emulgel. Clinical parameters were recorded at baseline, 1 month, and 3 months; these included plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL). Biochemical evaluations were conducted to measure the gingival crevicular fluid (GCF) interferon-gamma (IFN-y) level and total antioxidant capacity at baseline, 1 month, and 3 months. Results: All clinical variables improved after treatment in both groups, with significant improvement in Group II, which was higher than that in Group I at different intervals. The GCF total antioxidant level revealed a significant rise, while the IFN-y level showed a significant decrease throughout the study within both groups, with no significant difference between the 2 groups. Conclusion: Quercetin nano-emulgel showed promising results in improving clinical and biochemical parameters in treating periodontitis When used in conjunction with scaling and root planing. This encourages using quercetin nano-emulgel in clinical practice as an adjunctive treatment for stage I and II periodontitis.

KEYWORDS

Drug Delivery System; Emulgel; Nanomedicine; Periodontitis; Quercetin.

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Published

2025-04-01

Issue

Vol. 27 No. 4 (2024): Oct - Dec / 2024 - Published Oct 2024

Section

Clinical or Laboratorial Research

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All manuscript's copyright ownership of the article "____________________________________________________________________" is transferred from the author(s) to the BRAZILIAN DENTAL SCIENCE, in the event the work is published. The manuscript has not been published elsewhere and that it has not been submitted simultaneously for publication elsewhere.

We hereby attest the study is original and does not present manipulated data, fraud or plagiarism. We made significant scientific contribution to the study and we are aware of the presented data and in agreement with the final version of the manuscript. We assume complete responsibility for the ethical aspects of the study.

 

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