Efficacy of quercetin nano-emulgel as adjuvant local delivery drug in non-surgical treatment of periodontitis

Authors

  • Khoshoe Al-mokhtar Mohammed Assiut University, Faculty of Dentistry, Department of Oral Medicine, Periodontology, and Oral Diagnosis. Assiut, Egypt. https://orcid.org/0009-0002-7269-8578
  • Alzahraa A. Alghriany Assiut University, Faculty of Dentistry, Department of Oral Medicine, Periodontology, and Oral Diagnosis. Assiut, Egypt. https://orcid.org/0009-0009-8150-8255
  • Abdullah Ibrahim Abd Rabbouh Ali Al-Azhar University, Assiut Branch, Faculty of Dental Medicine, Department of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology. Assiut, Egypt. https://orcid.org/0009-0008-8514-210X
  • Helal F Hetta University of Tabuk, Faculty of Pharmacy, Department of Natural Products and Alternative Medicine, Division of Microbiology, Immunology and Biotechnology. Tabuk, Saudi Arabia. https://orcid.org/0000-0001-8541-7304
  • Ibrahim M Mwafey Al-Azhar University, Assiut Branch, Faculty of Dental Medicine, Department of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology. Assiut, Egypt. https://orcid.org/0009-0006-8106-9537

DOI:

https://doi.org/10.4322/bds.2024.e4419

Abstract

Objective: The objective of this study was to assess the impact of quercetin nano-emulgel on clinical and biochemical markers in patients with stage I and II periodontitis as an adjuvant to scaling and root planing (SRP). Material and Methods: Two groups were randomly assigned to 20 test sites from patients with stage I and II periodontitis: Group I, in which 10 sites got scaling and root planing, and Group II, in which 10 sites received scaling and root planing alongside quercetin nano-emulgel. Clinical parameters were recorded at baseline, 1 month, and 3 months; these included plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL). Biochemical evaluations were conducted to measure the gingival crevicular fluid (GCF) interferon-gamma (IFN-y) level and total antioxidant capacity at baseline, 1 month, and 3 months. Results: All clinical variables improved after treatment in both groups, with significant improvement in Group II, which was higher than that in Group I at different intervals. The GCF total antioxidant level revealed a significant rise, while the IFN-y level showed a significant decrease throughout the study within both groups, with no significant difference between the 2 groups. Conclusion: Quercetin nano-emulgel showed promising results in improving clinical and biochemical parameters in treating periodontitis When used in conjunction with scaling and root planing. This encourages using quercetin nano-emulgel in clinical practice as an adjunctive treatment for stage I and II periodontitis.

KEYWORDS

Drug Delivery System; Emulgel; Nanomedicine; Periodontitis; Quercetin.

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Published

2025-04-01

How to Cite

1.
Mohammed KA- mokhtar, A. Alghriany A, Ali AIAR, Hetta HF, Mwafey IM. Efficacy of quercetin nano-emulgel as adjuvant local delivery drug in non-surgical treatment of periodontitis. BDS [Internet]. 2025 Apr. 1 [cited 2025 Aug. 25];27(4). Available from: https://bds.ict.unesp.br/index.php/cob/article/view/4419

Issue

Vol. 27 No. 4 (2024): Oct - Dec / 2024 - Published Oct 2024

Section

Clinical or Laboratorial Research

License

Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.

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