Bovine and equine biomaterials in mandibular alveolar dog model: Split-mouth study

Authors

  • Willian Pecin Jacomacci Department of Oral Maxillofacial Surgery – State University of Maringá – Maringá – PR – Brazil.
  • Angelo José Pavan Department of Oral Maxillofacial Surgery – State University of Maringá – Maringá – PR – Brazil.
  • Jacqueline Nelisis Zanoni Department of Morphophysiological Sciences – State University of Maringá – Maringá – PR – Brazil.
  • Edevaldo Tadeu Camarini Department of Oral Maxillofacial Surgery – State University of Maringá – Maringá – PR – Brazil.

DOI:

https://doi.org/10.14295/bds.2016.v19i3.1291

Abstract

A predictable rehabilitation of severely atrophied alveolar ridge defects still remains a matter of concern in implant dentistry. Objective: The aim of this study was to compare histologically biomaterials of bovine (Genox®) and equine (Bio-Gen®) origin associated or not to platelet-rich plasma (PRP), analyzing bone maturity, amount of mature (type I) and immature (type III) collagen present at sixty and ninety days in post-extraction alveolus. Materials and Methods: Four Beagle dogs were used from which the six mandibular premolars were extracted.  The alveolus contained respectively: right side, Bio-Gen ® (group B),  preserved the clot (group C), Genox ® (group G); left side, Bio-Gen ® + PRP group (BP), Clot + PRP (group CP) and Genox ® + PRP (group GP). After sixty and ninety days, two dogs were sacrificed at each date and the pieces were histologically processed and stained with picrosirius red, a specific stain for analysis of different types of collagen. Results: Comparisons of the averages of mature collagen at 60 days indicated significant differences between Group G when compared to Groups C and B. The biomaterial of bovine origin demonstrated higher amounts of mature collagen in 90 days while the biomaterial of equine origin had a higher average of immature collagen in 90 days. Conclusion: Groups associated to PRP were effective in the production of mature and immature collagen. Genox® associated with PRP demonstrated a more advanced stage of bone regeneration presenting as an alternative to fill post-extraction alveolus.

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Published

2016-09-29

Issue

Vol. 19 No. 3 (2016): Jul. - Sep. / 2016 - Published September 2016

Section

Clinical or Laboratorial Research

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All manuscript's copyright ownership of the article "____________________________________________________________________" is transferred from the author(s) to the BRAZILIAN DENTAL SCIENCE, in the event the work is published. The manuscript has not been published elsewhere and that it has not been submitted simultaneously for publication elsewhere.

We hereby attest the study is original and does not present manipulated data, fraud or plagiarism. We made significant scientific contribution to the study and we are aware of the presented data and in agreement with the final version of the manuscript. We assume complete responsibility for the ethical aspects of the study.

 

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