Antibacterial Efficacy of Conventional Versus Herbal Products on Streptococcus mutans in Adult Population- a Systematic Review & Meta-analysis




Background:  Dental caries is challenging infectious disease, which is wide spread and difficult to control. Although it’s multifactorial, microorganisms especially cariogenic Streptococcus mutans plays a wide role in initiation and progression of dental caries. Objective: The present review mainly aimed to evaluate and assess the antibacterial efficacy of herbal versus conventional products on Streptococcus mutans. Data Sources: A search was execute in electronic database (i.e., PUBMEDCENTRAL, COCHRANE, LILAC, SCIENCEDIRECT, GOOGLE SEARCH) using following search terms alone and in combination by means of PUBMED search builder from January 1990 up to July 2019. Study Eligibility Criteria: Studies were stipulate if they met the following criteria: In vivo studies comparing herbal and conventional products on anticariogenic or antibacterial activity on Streptococcus mutans were selected. Participants and Intervention: Adult patients aged from 18-65 years with dental caries undergoing intervention of herbal products. Study Appraisal and Synthesis Material and Methods: Out of 225 studies collected from databases, only 6 studies were included and other 6 were collected by hand search. Finally 12 included studies were analyzed out of which 5 studies were considered for meta-analysis. Results: The results unveil that natural products exerted virtually homogeneous antibacterial effect against Streptococcus mutans when compared with the counterpart. Limitations: Review was assessing on patients with dental caries and studies previously assessed did not mention about the caries risk. Prevalence varies based on caries risk assessments. Study was concentrating only on single species Streptococcus mutans. But ideally caries is multifactorial. Conclusion: Although natural products were effective, the present systematic review does not furnish concrete evidence to a show increased antibacterial efficacy of natural products as compared to conventional products.


Antibiotics, Chlorhexidine, Dental Caries, Herbal, Streptococcus mutans.

Author Biographies

Kavalipurapu Venkata Teja, Kavalipurapu Venkata Teja BDS Vishnu Dental College India Mail id: +917397439814

Kavalipurapu Venkata Teja

Vishnu Dental College

Mail id: +917397439814

Apoorva Vasundhara Kaligotla, Kaligotla Apoorva Vasundhara Postgraduate Sibar Institute of Dental Sciences Guntur India Mail id: Ph no. +919701004909 ORCID ID:

Kaligotla Apoorva Vasundhara


Sibar Institute of Dental Sciences



Mail id:

Ph no. +919701004909

Sriram Gummuluri, B.Pharmacy undergraduate svs school of pharmacy /affliation JNTUH

B.Pharmacy IV year 

svs school of pharmacy

department of pharmacy




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